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What's in our Calm Me Supplement Kit?

Feeling a little stressed or anxious?

Now more than ever we are all feeling our stress levels increase, and a much higher number of us are said to have anxiety or feel anxious in our day to day lives. There are a number of things we can do nutritionally to help manage stress (we wrote a whole blog on it).

Whilst we all know a balanced diet should be your first port-of-call for getting your vitamins, minerals and other key nutrients, supplements are a great way to give you a helping hand: Calm Me is formulated to do just that when you’re feeling a little stressed or anxious, or finding it hard to get a good nights sleep.

Our Nutrition experts chose the ingredients specifically for their soothing properties. Meet our her active ingredients:

Magnesium: 'Nature's Relaxant'

Magnesium is an essential mineral that contributes to the reduction of tiredness, fatigue and normal-energy yielding metabolism, as well as balancing electrolyte levels. In Calm Me, the form of magnesium we use is malate, which is known to be the form which has a high absorption rate.

Magnesium malate, a combination of magnesium and malic acid (which is found in apples), is a salt formulation which are much more easily absorbed into the body. Various studies compare several different forms of magnesium supplements, and found that magnesium malate provided the most bioavailable magnesium (1).

Around 80% of the UK population have a deficiency of Magnesium. This is mainly due to soil deficiencies, not consuming enough foods that contain magnesium or having absorption issues within the gut.

Rhodiola : A Soothing Adaptogen

Rhodiola is an adaptogenic herb which means that it increases your body’s responses in stressful situations. People in Scandinavia and Russia have used Rhodiola to for anxiety, fatigue and depression for centuries. It has been studied to significantly improve symptoms of anxiety, stress and exhaustion (2).


5HTP is an amino acid that your body naturally produces. It is a precursor to serotonin, which is our ‘feel good’ neurotransmitter. Low serotonin is associated with low mood, depression, anxiety and the effects of 5HTP have been well studied. Several studies have found links between using 5HTP for reducing symptoms of depression (4).

Serotonin is converted into Melatonin in the body, which is our sleep hormone. It rises in the evening to promote sleep, and falls in the morning to help us to wake up, which is when our cortisol levels spikes. Supplementing with 5-HTP may promote sleep by increasing melatonin production in your body (5).


Theanine is an amino acid which is naturally found in tea, in particular green tea.

Tea is known to be a rich source of flavonoid antioxidants. However, tea also contains a unique amino acid, L-theanine that may modulate aspects of brain function in humans.

Research indicates that L-Theanine supports relaxation without drowsiness. It is often used to relax and unwind, and to help ease stress (3).

Calcium: More than just a bone-building nutrient

Calcium contributes to the normal function of digestive enzymes, normal energy-yielding metabolism and neurotransmission.

A neurotransmitter is a chemical messenger that carries, boosts, and balances signals between neurons, examples of neurotransmitters include hormones like melatonin, serotonin, acetylcholine and noradrenaline.

Therefore, calcium can help to support the sleep cycle and the transmission of our ‘feel good’ hormone, serotonin, contributing to optimal brain function (6).

B Vitamins:

B vitamins (B1,2,3, 5,6,7,9,12) contribute to reduction of tiredness and fatigue, normal energy-yielding metabolism, regulation of hormonal activity and normal function of the immune system. Certain B vitamins also play a role as co-enzymes which support the nervous system, and brain function (7).

Neurotransmitters are made within our neurons via the interaction of various chemicals – including several B-vitamins. For instance, vitamin B6 supports the formation of neurotransmitters like dopamine, which is involved in our experience of reward, happiness and pleasure. B6 deficiency and dopamine levels have has been studied for their role in depressive symptoms (8).



  1. Uysal, N. Kizildag, S. Yuce, Z. et al. Timeline (Bioavailability) of Magnesium Compounds in Hours: Which Magnesium Compound Works Best?. Biological Trace Element Research, 187(1), pp.128-136.
  3. Edwards, D. Heufelder, A. Zimmermann, A. Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms--results of an open-label study. Phytother Res., 26(8), pp.1220-5.
  5. Nobre, A. Rao, A. Owen, G. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr, 17(1), pp.167-168.
  7. Javelle, F. Lampit, A. Bloch, W. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis. Nutrition Reviews, 78(1), pp.77–88.
  9. Tordjman, S. Chokron, S. Delorme, R. 2017. Melatonin: Pharmacology, Functions and Therapeutic Benefits. Current Neuropharmacology, 15(3), pp.434-443.
  11. Sudhof, T. Calcium Control of Neurotransmitter Release. Cold Spring Harbor Perspectives in Biology, 4(1), pp.a011353-a011353.
  13. Kennedy, D. 2016. B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review. Nutrients, 8(2), p.68.
  15. Tang, F. and Wei, I. 2004. Vitamin B-6 deficiency prolongs the time course of evoked dopamine release from rat striatum. The Journal of Nutrition, 132(12), pp.3350–3354.